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C and 
HeAkeo, Kiyoshi*; Funayama, Tomoo; Kobayashi, Yasuhiko; Akeo, Yoko*
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 80, 2015/03
It is known that superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Ionizing radiation is known to induce oxidative stress through generation of reactive oxygen species resulting in imbalance of the pro-oxidant and antioxidant in the cells, which is suggested to culminate in cell death. Therefore, we measured the activity of SOD in human RE cells exposed to the He- and C-ion beam. The cells collected at 0, 4, 8, and 24 hr after irradiation were extracted by adding the SOD assay buffer to the pellets, and lysed by several cycles of freezing and thawing. The activity of SOD was measured using a modification of the luminol assay. SOD activity decreased according to duration time after irradiation of He-ion, however, in case of C-ion, it increased at 24 hr after irradiation. The result suggested that that there were the differences of the effects by irradiation on SOD activity between He- and C-ion.
Akamatsu, Ken; Yokoya, Akinari
JAERI-Research 2002-015, 30 Pages, 2002/08
JAERI-Research-2002-015.pdf:1.27MB
no abstracts in English
Tsujimura, Norio; Shinohara, Kunihiko; Momose, Takumaro
PNC TN8410 97-207, 25 Pages, 1997/06
None
Yoshida, Masaru; Asano, Masaharu; Omichi, Hideki; *; *; *
Int. J. Pharm., 115, p.61 - 67, 1995/00
Times Cited Count：2 Percentile：8.48(Pharmacology & Pharmacy)no abstracts in English
Yonezawa, Chushiro; *; *; Hoshi, Michio; Tachikawa, Enzo; Kabuto, Michinori*; *
Bunseki Kagaku, 41, p.581 - 587, 1992/00
no abstracts in English
Manabe, Kentaro; Takahashi, Fumiaki
no journal, ,
A dose estimation system which integrates external and internal exposure is being developed to contribute to radiation protection for members of the public from radionuclides released into the environment. For internal exposure, inhalation of radioactive aerosols should be considered, and internal doses by inhalation depend on their diameters, densities, shape. However, dose coefficients published by the International Commission on Radiological Protection (ICRP) are developed with the assumption that distribution of particle diameters has a specific log-normal distribution. In addition, the existing codes can consider only a single value or a log-normal distribution for diameters of particles and do not fit the divisions of particle deposition determined by the revised Human Respiratory Tract Model (revised HRTM). Therefore, we developed a function of the dose estimation system which can calculate deposition fractions of inhaled particles having a given diameter distribution, density, and shape factor using the deposition model of ICRP. This function reproduced the deposition fractions for adult males in a light exertion level. In future, this function will be put in the dose estimation system to calculate internal dose coefficients under various conditions.
